Article

Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition

2026-03-26

Abstract excerpt

Nav1.7 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and selective Nav1.7 inhibitors have been developed as possible therapeutic agents for treating pain, so far with disappointing clinical results. In contrast, a selective Nav1.8 channel inhibitor (suzetrigine) has had successful clinical trials. Because nociceptors express both Nav1.7 and Nav1.8 channels...

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Literature Corpus work: 7f9ff018-72ca-5cf6-9b4f-cde2f186ac8d
DOI: 10.64898/2026.03.26.714428

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