Article

A mechanistic model of protein kinase A dynamics under pro- and anti-nociceptive inputs

2026-02-14

Abstract excerpt

Protein kinase A (PKA) is a central integrator of nociceptive signaling, yet a quantitative account of how pro- and anti-nociceptive inputs shape its dynamics remains incomplete. Here, we develop a mechanistic model of PKA activity in nociceptive neurons that explicitly links receptor activation to downstream kinase regulation. Using time-course and dose-response measurements, we infer unknown process parameters a...

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Identifiers and source

Literature Corpus work: 83ddeda4-6572-5666-8c54-e465fa9e6bd5
DOI: 10.64898/2026.02.12.705506

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