Article

Modulation of Voltage-Gated Sodium Channel (VGSC) Activity in Human Dorsal Root Ganglion (DRG) Neurons by Herpesvirus Quiescent Infection

2019-07-25

Abstract excerpt

The molecular mechanisms of pain associated with alphaherpesvirus latency are not clear. We hypothesize that the voltage-gated sodium channels (VGSC) on dorsal root ganglion (DRG) neurons controlling electrical impulses may have abnormal activity during viral latent infection and reactivation. We used HSV-1 to infect human DRG-derived neuronal cell line HD10.6 to study viral latency establishment, maintenance and...

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Literature Corpus work: 6accca71-7ad4-51c0-ae75-633eb97db470
DOI: 10.1101/714691

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