Article

Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model

2025-06-10

Abstract excerpt

Spinal motoneurons are the final output of spinal circuits that engage skeletal muscles to generate motor behaviors. Many motoneurons exhibit bistable behavior, alternating between a quiescent resting state and a self-sustained firing mode, classically attributed to plateau potentials driven by persistent inward currents. This intrinsic property is important for normal movement control, but can become dysregulated...

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Literature Corpus work: 23f01192-9438-520e-a7bc-63a67e6a014b
DOI: 10.1101/2025.06.06.658369

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