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Article

Dexmedetomidine alleviates LPS-induced neuronal dysfunction via AKT/GSK-3β/CRMP-2 pathway

2020-06-04

Abstract excerpt

<h4>Background: </h4> Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, shows intervention effect on cognitive dysfunction in elderly patients after general anesthesia. However, the underlying pathological mechanism remains to be further elucidated. The aim of the study was to investigate effects of Dex on LPS-induced neuronal damages in cultured hippocampal neurons. Methods We applied LPS to mimic the po...

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Literature Corpus work
a03cf7fd-4ec3-5799-9c4a-8d4802de1559
DOI
10.21203/rs.3.rs-27596/v1
Open publication

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