Article

ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis

2020-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to pain hypersensitivity in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Inflammatory cells and increased levels of ER stress markers are evident i...

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Literature Corpus work: 433685de-bf35-5f8b-990d-9df4326e3ed0
DOI: 10.1101/2020.01.22.915546

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