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Telomere-induced senescence increases aberrant intraneuronal amyloid-β accumulation by impairing autophagy in a mouse model of Alzheimer’s disease

2022-10-21

Abstract excerpt

Aging is a well-known risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes occurring in the aging brain are poorly understood. AD pathology seems to correlate with the appearance of cells that become senescent due to the progressive accumulation of cellular insults causing DNA damage. In this study, we investigated the role of cellular senescence...

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Literature Corpus work
3c350956-d29f-5868-943d-8bcdce857391
DOI
10.1101/2022.10.17.512098
Open publication

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Telomere-induced senescence increases aberrant intraneuronal amyloid-β accumulation by impairing autophagy in a mouse model of Alzheimer’s diseaseDOI 10.1101/2022.10.17.512098
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