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Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse model

2025-06-06

Abstract excerpt

<h4>Background</h4> Although the connection between aging and neurodegenerative pathologies like Alzheimer’s disease (AD) has long been recognized, the underlying pathological mechanisms remain largely unknown. Senescent brain cells build up in the brains of AD patients and a causal link has been established between senescence and AD-related tauopathy. <h4>Methods</h4> To investigate the role of cellular senesce...

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Literature Corpus work
4eec2471-4b23-5791-85b7-19fb01bab521
DOI
10.1101/2025.06.03.657581
Open publication

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Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse modelDOI 10.1101/2025.06.03.657581
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