Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senescence Targeting Methods Impact Alzheimer’s Disease Features in 3xTg Mice

30 Jan 2024

Abstract excerpt

Background: Cellular senescence has been associated with neurodegenerative disease and clearance of senescent cells using genetic or pharmaceutical strategies (senolytics) has demonstrated beneficial effects in mouse models investigating individual disease etiologies of Alzheimer's disease (AD). However, it has remained unclear if senescent cell clearance in a mouse model exhibiting both plaque and tau...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38306030
DOI: 10.3233/jad-230465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescence Targeting Methods Impact Alzheimer’s Disease Features in 3xTg MicePMID 38306030Read ↗

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in miceSemantic proximity Read ↗

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse modelSemantic proximity Read ↗

Tau protein aggregation induces cellular senescence in the brainSemantic proximity Read ↗

Telomere-induced senescence increases aberrant intraneuronal amyloid-β accumulation by impairing autophagy in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathologySemantic proximity Read ↗

Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomicsSemantic proximity Read ↗

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologySemantic proximity Read ↗

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologySemantic proximity Read ↗

Cellular Senescence Is a Central Driver of Cognitive Disparities in AgingSemantic proximity Read ↗

Tau protein aggregation is associated with cellular senescence in the brainSemantic proximity Read ↗

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP <sup>NL-F/NL-F</sup> MiceSemantic proximity Read ↗

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.