Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain

Abstract excerpt

<h4> Abstract </h4> Most existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to research molecular mechanisms underlying brain disorders and diseases. Initial studies comparing brain to blood primarily at the individual CpG level analysis have generally pointed to a limited overlap of epigenetic patterns, consistent with DNAm being largely tissue- and even cell type-specific. Expanding...

Topics

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• Autopsy
• Base Composition
• Conserved Sequence
• CpG Islands
• Diabetes and associated disorders
• Gene Regulatory Networks
• Longitudinal Studies
• Molecular Sequence Annotation

Identifiers and source

Literature Corpus work

3c306660-bc0d-5bcd-8248-6f4266785547

DOI

10.1101/2025.08.25.672204