Article
A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory.
Nature communications - 26 Apr 2017
Freytag Virginie, Carrillo-Roa Tania, Milnik Annette, Sämann Philipp G, Vukojevic Vanja, Coynel David, Demougin Philippe, Egli Tobias, Gschwind Leo, Jessen Frank, Loos Eva, Maier Wolfgang, Riedel-Heller Steffi G, Scherer Martin, Vogler Christian, Wagner Michael, Binder Elisabeth B, de Quervain Dominique J-F, Papassotiropoulos Andreas
Abstract excerpt
Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10-8) and memory performance in 533 healthy young adults. The...
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