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Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

27 May 2025

Abstract excerpt

Variations in immune-cell fractions can confound or hamper interpretation of DNAm-based biomarkers in blood. Although cell-type deconvolution can address this challenge for cord and adult blood, currently there is no method applicable to blood from other age groups, including infants and children. Here we construct and extensively validate a DNAm reference panel, called UniLIFE, for 19 immune cell-types,...

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PMID: 40426256
DOI: 10.1186/s13073-025-01489-7

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