Article
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes.
Genome medicine - 31 Jul 2023
Luo Qi, Dwaraka Varun B, Chen Qingwen, Tong Huige, Zhu Tianyu, Seale Kirsten, Raffaele Joseph M, Zheng Shijie C, Mendez Tavis L, Chen Yulu, Carreras Natalia, Begum Sofina, Mendez Kevin, Voisin Sarah, Eynon Nir, Lasky-Su Jessica A, Smith Ryan, Teschendorff Andrew E
Abstract excerpt
BACKGROUND: Changes in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally implicated in disease development and progression. However, these shifts in cell-type fractions are often of a low magnitude, or involve similar cell subtypes, making their reliable identification challenging. DNA methylation profiling in a tissue like blood is a...
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