Article

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer’s disease and epilepsy and predisposes to seizures

2020-03-23

Abstract excerpt

<h4>ABSTRACT</h4> In astrocytes, calcineurin (CaN) is involved in neuroinflammation and gliosis, while its role in healthy CNS or in early neuro-pathogenesis is poorly understood. Here we report that in astroglial CaN KO (ACN-KO) mice, at one month of age, proteome is deranged in hippocampus and cerebellum. Bioinformatic analysis reveals association with Alzheimer’s disease (AD) and epilepsy. We found significant...

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Literature Corpus work: 1522cf6a-0112-5d9c-8b2e-cd0b6d412325
DOI: 10.1101/2020.03.21.001321

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