Article
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
Genome research - 1 Sept 2015
Deng Tao, Zhu Z Iris, Zhang Shaofei, Postnikov Yuri, Huang Di, Horsch Marion, Furusawa Takashi, Beckers Johannes, Rozman Jan, Klingenspor Martin, Amarie Oana, Graw Jochen, Rathkolb Birgit, Wolf Eckhard, Adler Thure, Busch Dirk H, Gailus-Durner Valérie, Fuchs Helmut, Hrabě de Angelis Martin, van der Velde Arjan, Tessarollo Lino, Ovcherenko Ivan, Landsman David, Bustin Michael
Abstract excerpt
DNase I hypersensitive sites (DHSs) are a hallmark of chromatin regions containing regulatory DNA such as enhancers and promoters; however, the factors affecting the establishment and maintenance of these sites are not fully understood. We now show that HMGN1 and HMGN2, nucleosome-binding proteins that are ubiquitously expressed in vertebrate cells, maintain the DHS landscape of mouse embryonic fibroblasts (MEFs)...
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