Article

High-resolution and High-accuracy Topographic and Transcriptional Maps of the Nucleosome Barrier

2019-05-17

Abstract excerpt

Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nucleosome crossing dynamics, is still missing. Here, we obtain topographic and transcriptional (Pol II residence time) maps of canonical, H2A.Z, and monoubiquitina...

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Literature Corpus work: dd3c307d-413e-5898-a1cf-4b835bf76031
DOI: 10.1101/641506

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