Article

Genome-wide strand asymmetry in massively parallel reporter activity favors genic strands

2020-08-27

Abstract excerpt

Massively parallel reporter assays (MPRAs) are useful tools to discover and characterize regulatory elements in human genomes. Partly because enhancer function is assumed to be orientation independent with respect to each strand of the DNA helix, most reported MPRA results ignore stranded information. However, we find pervasive strand asymmetry of MPRA signals in datasets from multiple reporter configurations and...

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Literature Corpus work: 3beb72ea-e1c9-54c6-9615-07a2cd9ee409
DOI: 10.1101/2020.08.26.269027

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