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Article

Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespan

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Long Interspersed Nucleotide Element-1 (LINE-1, or L1) sequences occupy approximately 17% of the human genome. L1 RNA expression, required for embryogenesis, is low in middle childhood, but increases in adults, eroding heterochromatin and leading to ectopic gene misexpressions, sterile chronic inflammation, and physiological deterioration. To our knowledge, no studies have y...

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Identifiers and source

Literature Corpus work
3bc96b63-ce4c-51be-913c-f2cb40a9a7ef
DOI
10.64898/2025.12.17.25342501
Open publication

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Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespanDOI 10.64898/2025.12.17.25342501
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