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Article

Genes associated with the cis-regulatory functions of intragenic LINE-1 elements

27 Mar 2013

Abstract excerpt

BACKGROUND: Thousands of intragenic long interspersed element 1 sequences (LINE-1 elements or L1s) reside within genes. These intragenic L1 sequences are conserved and regulate the expression of their host genes. When L1 methylation is decreased, either through chemical induction or in cancer, the intragenic L1 transcription is increased. The resulting L1 mRNAs form RISC complexes with pre-mRNA to degrade the...

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PMID: 23530910
DOI: 10.1186/1471-2164-14-205

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