Article

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers

2024-09-11

Abstract excerpt

<h4>ABSTRACT</h4> LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ∼17% and ∼11% of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery to mobilize autonomously, Alu and degenerate L1s can hijack their functional machinery and mobilize in trans . The expression and subsequent mobilization of L1 and Alu can exert pathological effe...

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Literature Corpus work: 6e29fdf5-f870-5cc5-8521-f14eb4b7f134
DOI: 10.1101/2024.09.10.612283

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