Article

The fitness cost of a congenital heart defect shapes its genetic architecture

2019-01-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In newborns, severe congenital heart defects are rarer than mild ones. The reason why is unknown, but presumably related to a liability threshold that rises with the severity of a defect. Because the same genetic mutation can cause different defects, other variables may contribute to pushing an individual past a defect-specific liability threshold. We consider here how varia...

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Literature Corpus work: 3bc221bc-9db1-5445-a7bd-92ce28e8fc99
DOI: 10.1101/531988

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