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Article

Genetic Assembly of the Heart: Implications for Congenital Heart Disease

1 Mar 2001

Abstract excerpt

More children die from congenital heart defects (CHD) each year than are diagnosed with childhood cancer, yet the causes remain unknown. The remarkable conservation of genetic pathways regulating cardiac development in species ranging from flies to humans provides an opportunity to experimentally dissect the role of critical cardiogenic factors. Utilization of model biological systems has resulted in a molecular...

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PMID: 11181963
DOI: 10.1146/annurev.physiol.63.1.451

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