Article
Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.
Circulation research - 10 Nov 2000
Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott D A, Barnett L, Köentgen F, Robb L, Feneley M, Harvey R P
Abstract excerpt
Heterozygous mutations in the cardiac homeobox gene, NKX2-5, underlie familial cases of atrial septal defect (ASD) with severe atrioventricular conduction block. In this study, mice heterozygous for Nkx2-5-null alleles were assessed for analogous defects. Although ASD occurred only rarely, atrial septal dysmorphogenesis was evident as increased frequencies of patent foramen ovale and septal aneurysm, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.