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Article

Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation.

Circulation. Cardiovascular genetics - 1 Jun 2012

Winston Julia B, Schulkey Claire E, Chen Iuan-Bor D, Regmi Suk D, Efimova Maria, Erlich Jonathan M, Green Courtney A, Aluko Ashley, Jay Patrick Y

Abstract excerpt

BACKGROUND: The occurrence of a congenital heart defect has long been thought to have a multifactorial basis, but the evidence is indirect. Complex trait analysis could provide a more nuanced understanding of congenital heart disease. METHODS AND RESULTS: We assessed the role of genetic and environmental factors on the incidence of ventricular septal defects (VSDs) caused by a heterozygous Nkx2-5 knockout...

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Share to Aneuploidy
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Heart Septal Defects, Ventricular

Share to Homeobox Protein Nkx-2.5

Share to Homeodomain Proteins

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Share to Mice, Knockout

Source

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Identifiers

PMID: 22534315
DOI: 10.1161/CIRCGENETICS.111.961136
PMCID: PMC3521568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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