Article

Negative selection on human genes causing severe inborn errors depends on disease outcome and both the mode and mechanism of inheritance

2020-02-08

Abstract excerpt

<h4>Background</h4> Genetic variants underlying severe diseases are less likely to be transmitted to the next generation, and are thus gradually and selectively eliminated from the population through negative selection. Here, we study the determinants of this evolutionary process in genes underlying severe diseases in humans. <h4>Results</h4> We propose a novel approach, CoNeS, integrating known negative selecti...

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Literature Corpus work: fb25ef1d-c8a1-57fd-8356-b1f5dbde2468
DOI: 10.1101/2020.02.07.938894

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