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Article

Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway.

PLoS genetics - 1 Dec 2019

Sucharov Juliana, Ray Kuval, Brooks Elliott P, Nichols James T

Abstract excerpt

Deleterious genetic mutations allow developmental biologists to understand how genes control development. However, not all loss of function genetic mutants develop phenotypic changes. Many deleterious mutations only produce a phenotype in a subset of mutant individuals, a phenomenon known as incomplete penetrance. Incomplete penetrance can confound analyses of gene function and our understanding of this...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31790396
DOI: 10.1371/journal.pgen.1008507
PMCID: PMC6907857

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