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Article

Heterogeneity of genetic modifiers ensures normal cardiac development.

Circulation - 23 Mar 2010

Winston Julia B, Erlich Jonathan M, Green Courtney A, Aluko Ashley, Kaiser Kristine A, Takematsu Mai, Barlow Robert S, Sureka Ashish O, LaPage Martin J, Janss Luc L, Jay Patrick Y

Abstract excerpt

BACKGROUND: Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. METHODS AND RESULTS: Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial and ventricular...

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Share to Heart
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Atrial

Share to Heart Septal Defects, Ventricular

Share to Homeobox Protein Nkx-2.5

Share to Homeodomain Proteins

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Share to Mice, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 20212279
DOI: 10.1161/CIRCULATIONAHA.109.887687
PMCID: PMC2953850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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