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Article

Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line.

eLife - 5 Jun 2023

Moradi Marjaneh Mahdi, Kirk Edwin P, Patrick Ralph, Alankarage Dimuthu, Humphreys David T, Del Monte-Nieto Gonzalo, Cornejo-Paramo Paola, Janbandhu Vaibhao, Doan Tram B, Dunwoodie Sally L, Wong Emily S, Moran Chris, Martin Ian C A, Thomson Peter C, Harvey Richard P

Abstract excerpt

Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. Atrial and ventricular septal defects are the most common forms of cardiac congenital anomalies in humans. Atrial septal defects (ASD) show an open communication between the left and right atria postnatally, potentially...

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Identifiers

PMID: 37272612
DOI: 10.7554/eLife.83606
PMCID: PMC10284603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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