Article

Deciphering Mutational Signature Dynamics in Hormone-Sensitive Breast Cancer During Treatment Adaptation.

2023-10-20

Abstract excerpt

<title>Abstract</title> <p>The DNA accumulates somatic changes before and after tumor initiation. These changes have been classified into mutational signatures (1) but only recently have studies begun to experimentally validate and functionally dissect these signatures. The role of the underlying functional annotation of DNA and long-term exposure to endocrine therapies in shaping signatures in breast cancer rema...

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Literature Corpus work: 3babf1cf-1828-54b0-94a9-7e52dac78be0
DOI: 10.21203/rs.3.rs-3443614/v1

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