The topography of mutational processes in breast cancer genomes.

doi:10.1038/ncomms11383

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Article

The topography of mutational processes in breast cancer genomes.

Nature communications - 2 May 2016

Morganella Sandro, Alexandrov Ludmil B, Glodzik Dominik, Zou Xueqing, Davies Helen, Staaf Johan, Sieuwerts Anieta M, Brinkman Arie B, Martin Sancha, Ramakrishna Manasa, Butler Adam, Kim Hyung-Yong, Borg Åke, Sotiriou Christos, Futreal P Andrew, Campbell Peter J, Span Paul N, Van Laere Steven, Lakhani Sunil R, Eyfjord Jorunn E, Thompson Alastair M, Stunnenberg Hendrik G, van de Vijver Marc J, Martens John W M, Børresen-Dale Anne-Lise, Richardson Andrea L, Kong Gu, Thomas Gilles, Sale Julian, Rada Cristina, Stratton Michael R, Birney Ewan, Nik-Zainal Serena

Abstract excerpt

Somatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutational signature on...

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PMID: 27136393
DOI: 10.1038/ncomms11383
PMCID: PMC5001788

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