Article

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

2023-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Transcription and splicing of pre-messenger RNA are closely coordinated, but how this functional coupling is disrupted in human disease remains unexplored. Here, we investigated the impact of non-synonymous mutations in SF3B1 and U2AF1, two commonly mutated splicing factors in cancer, on transcription. We find that the mutations impair RNA Polymerase II (RNAPII) transcription elongation along ge...

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Literature Corpus work: 296b2a9d-2a7f-5b02-ba6c-9016979e6acb
DOI: 10.1101/2023.02.25.530019

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