Article
Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay.
Molecular cell - 1 Oct 2002
Wang Jun, Chang Yao Fu, Hamilton John I, Wilkinson Miles F
Abstract excerpt
Nonsense-associated altered splicing (NAS) is a putative correction response that upregulates alternatively spliced transcripts that have skipped offending premature termination codons (PTCs). Here, we examined whether NAS has characteristics in common with nonsense-mediated decay (NMD), a surveillance mechanism that degrades PTC-bearing mRNAs. We discovered that although NAS shared the need for a Kozak AUG to...
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