Article
Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes.
Bioinformatics (Oxford, England) - 1 Jan 2003
Green Richard E, Lewis Benjamin P, Hillman R Tyler, Blanchette Marco, Lareau Liana F, Garnett Aaron T, Rio Donald C, Brenner Steven E
Abstract excerpt
We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003; PROC: Natl Acad. Sci. USA, 100, 189-192). Rather than being translated to yield protein, these transcripts are expected to be degraded and may be subject to regulated unproductive splicing and translation (RUST). Our initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.