Article
Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes.
Bioinformatics (Oxford, England) - 1 Jan 2003
Green Richard E, Lewis Benjamin P, Hillman R Tyler, Blanchette Marco, Lareau Liana F, Garnett Aaron T, Rio Donald C, Brenner Steven E
Abstract excerpt
We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003; PROC: Natl Acad. Sci. USA, 100, 189-192). Rather than being translated to yield protein, these transcripts are...
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