Article
Regulation of nonsense-mediated mRNA decay in neural development and disease.
Journal of molecular cell biology - 4 Aug 2021
Lee Paul Jongseo, Yang Suzhou, Sun Yu, Guo Junjie U
Abstract excerpt
Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes. Among them, nonsense-mediated mRNA decay (NMD) functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism targeting numerous physiological mRNAs. Despite its...
Topics
- Animals
- Central Nervous System
- Codon, Nonsense
- Gene Expression Regulation, Developmental
- Humans
- Mutation
- Neurodevelopmental Disorders
- Nonsense Mediated mRNA Decay
- Protein Biosynthesis
- RNA, Messenger