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Article

Regulation of nonsense-mediated mRNA decay in neural development and disease.

Journal of molecular cell biology - 4 Aug 2021

Lee Paul Jongseo, Yang Suzhou, Sun Yu, Guo Junjie U

Abstract excerpt

Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes. Among them, nonsense-mediated mRNA decay (NMD) functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism targeting numerous physiological mRNAs. Despite its...

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Identifiers

PMID: 33783512
DOI: 10.1093/jmcb/mjab022
PMCID: PMC8339359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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