Article
Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.
Molecular nutrition & food research - 1 Mar 2024
Leclerc Daniel, Christensen Karen E, Reagan Alaina M, Keser Vafa, Luan Yan, Malysheva Olga V, Wasek Brandi, Bottiglieri Teodoro, Caudill Marie A, Howell Gareth R, Rozen Rima
Abstract excerpt
SCOPE: Disturbances in one-carbon metabolism contribute to nonalcoholic fatty liver disease (NAFLD) which encompasses steatosis, steatohepatitis, fibrosis, and cirrhosis. The goal is to examine impact of folate deficiency and the Mthfr677C >T variant on NAFLD. METHODS AND RESULTS: This study uses the new Mthfr677C >T mouse model for the human MTHFR677C >T variant. Mthfr677CC and Mthfr677TT mice were fed control...
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