Article

Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

2025-05-02

Abstract excerpt

Mitochondrial heteroplasmy, the co-existence of different mitochondrial genomes within a cell, is linked to aging and disease. Patients with heteroplasmy due to mitochondrial mutations experience multiple organ complications, particularly poor bone health and bone structure defects. However, the mechanisms involved are generally unknown, due largely to the difficulty of manipulating mtDNA in vivo. To overcome this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2a61042-d02c-5f61-ab09-1f22f8d24476
DOI: 10.1101/2025.05.02.651799

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex IDOI 10.1101/2025.05.02.651799Read

Detecting respiratory chain deficiency in osteoblasts of older patientsSemantic proximity Read

PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and ActivationSemantic proximity Read

Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging.Semantic proximity Read

Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do?Semantic proximity Read

Skeletal Phenotypes Due to Abnormalities in Mitochondrial Protein Homeostasis and Import.Semantic proximity Read

Mitophagy Deficiency Drives Skeletal Muscle Aging: Translational Evidence for Urolithin A and Spermidine in Reversing Primary SarcopeniaSemantic proximity Read

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice.Semantic proximity Read

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes.Semantic proximity Read

Detecting respiratory chain defects in osteoblasts from osteoarthritic patients using imaging mass cytometry.Semantic proximity Read

Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy DonorsSemantic proximity Read

The role and intervention of mitochondrial metabolism in osteoarthritisSemantic proximity Read

Mitochondrial Dysfunction in Obesity and ReproductionSemantic proximity Read