Article

High Expression of MRE11A, the Gene Involved in the Resection Step During Homologous Recombination, Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients

2023-05-16

Abstract excerpt

<h4>Background: </h4> Homologous Recombination (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency in this mechanism is a frequent event in tumorigenesis. Therapies that exploit defects in HR have been explored essentially in breast, ovarian, pancreas, and prostat...

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Literature Corpus work: 3b88c348-1612-553a-a405-bff30c2986c9
DOI: 10.20944/preprints202305.1126.v1

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