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The largest Chinese cohort study indicates homologous recombination pathway gene mutations as another major genetic risk factor for colorectal cancer with heterogeneous clinical phenotypes

2023-07-21

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) is one of the most common malignancies globally with estimated 1.87 million new cases annually. Genetic factors were associated with over 30% of CRC incidence. However, the mutations in CRC-susceptibility genes recommended by the National Comprehensive Cancer Network (NCCN) guidelines accounted for only 5-10% of CRC cases, suggesting a large proportion of CRC-susceptib...

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Literature Corpus work: b1bf2596-3e46-58ef-b4b5-cfe4b2a57de6
DOI: 10.21203/rs.3.rs-3174582/v1

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