Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA repair-dependent immunogenic liabilities in colorectal cancer: opportunities from errors

13 Sept 2024

Abstract excerpt

Colorectal cancer (CRC) remains one of the major causes of cancer death worldwide. Chemotherapy continues to serve as the primary treatment modality, while immunotherapy is largely ineffective for the majority of CRC patients. Seminal discoveries have emphasized that modifying DNA damage response (DDR) mechanisms confers both cell-autonomous and immune-related vulnerabilities across various cancers. In CRC,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39271762
DOI: 10.1038/s41416-024-02848-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA repair-dependent immunogenic liabilities in colorectal cancer: opportunities from errorsPMID 39271762Read ↗

Exploiting DNA repair defects in colorectal cancerSemantic proximity Read ↗

Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal CancerSemantic proximity Read ↗

Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal CancerSemantic proximity Read ↗

Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic ImplicationsSemantic proximity Read ↗

Biomarkers for immune therapy in colorectal cancer: mismatch-repair deficiency and othersSemantic proximity Read ↗

Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancerSemantic proximity Read ↗

Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging TherapiesSemantic proximity Read ↗

Mismatch repair deficient colorectal cancer in the era of personalized treatment.Semantic proximity Read ↗

Mutations in Homologous Recombination Repair Genes in Colorectal Cancer Are Associated With Favorable Response to Immune Checkpoint InhibitorsSemantic proximity Read ↗

Advances in DNA damage response inhibitors in colorectal cancer therapySemantic proximity Read ↗

Identification of DNA Repair-related Genes as Biomarkers Reflecting MSI, TMB, and TIL in Colorectal Cancer.Semantic proximity Read ↗

The role of DNA mismatch repair in immunotherapy of human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.