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The intersection of homologous recombination (HR) and mismatch repair (MMR) pathways in DNA repair-defective tumors

5 Sept 2024

Abstract excerpt

Homologous recombination (HR) and mismatch repair (MMR) defects are driver mutational imprints and actionable biomarkers in DNA repair-defective tumors. Although usually thought as mutually exclusive pathways, recent preclinical and clinical research provide preliminary evidence of a functional crosslink and crosstalk between HRR and MMR. Shared core proteins are identified as key players in both pathways,...

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PMID: 39237751
DOI: 10.1038/s41698-024-00672-0

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