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Exploiting DNA repair defects in colorectal cancer

4 Feb 2019

Abstract excerpt

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Therapies that take advantage of defects in DNA repair pathways have been explored in the context of breast, ovarian, and other tumor types, but not yet systematically in CRC. At present, only immune checkpoint blockade therapies have been FDA approved for use in mismatch repair-deficient colorectal tumors. Here, we discuss how...

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PMID: 30714316
DOI: 10.1002/1878-0261.12467

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