Article

Evidence of target-mediated miRNA degradation in <i>Drosophila</i> ovarian cell culture

2023-08-30

Abstract excerpt

Target-mediated miRNA degradation (TDMD) is a recently discovered process of post-transcriptional regulation of miRNA stability in animals. TDMD is induced by the formation of the non-canonical duplex of Ago-bound miRNAs with the specialized RNA target, and, as suggested for human cell culture, this complex is recognized by the ZSWIM8 receptor protein of the Cullin-RING-ligase complex CRL3. CRL3 ubiquitinates Ago,...

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Literature Corpus work: 3b76a03d-589b-5ce0-9606-22e2fc819f72
DOI: 10.1101/2023.08.30.555489

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