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Dora, a key component of target-directed miRNA degradation, is essential for local genomic amplification in <i>Drosophila</i> ovarian follicle cells

2025-02-21

Abstract excerpt

The ubiquitin ligase receptor Dora, the Drosophila homolog of ZSWIM8, is a key component of the target-directed microRNA degradation (TDMD) pathway. Previous studies have implicated TDMD – and, consequently, ZSWIM8/Dora – in various developmental processes. Here, we investigate the role of Dora in Drosophila oogenesis, focusing on its function in ovarian somatic cells. We generated a fly strain with an endogenou...

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Literature Corpus work
61d07210-07cd-5700-9a9f-9b39e4c6f6dd
DOI
10.1101/2025.02.20.639214
Open publication

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Dora, a key component of target-directed miRNA degradation, is essential for local genomic amplification in <i>Drosophila</i> ovarian follicle cellsDOI 10.1101/2025.02.20.639214
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