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Article

A dead end for microRNAs.

Cell - 28 Dec 2007

Ketting René F

Abstract excerpt

Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide evidence that Dnd1 mediates these effects by counteracting microRNA-mediated silencing of mRNAs.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18160032
DOI: 10.1016/j.cell.2007.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A dead end for microRNAs.PMID 18160032Read ↗

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.Semantic proximity Read ↗

The solution structure of Dead End bound to AU-rich RNA reveals an unprecedented mode of tandem RRM-RNA recognition required for mRNA regulationSemantic proximity Read ↗

The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafishSemantic proximity Read ↗

Identification of Two Novel Proteins That Interact with Germ-Cell-Specific RNA-Binding Proteins DAZ and DAZL1Semantic proximity Read ↗

Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testesSemantic proximity Read ↗

microRNAs in Drosophila regulate cell fate by repressing single mRNA targets.Semantic proximity Read ↗

Putative biological functions of the DAZ family.Semantic proximity Read ↗

microRNAs: runts of the genome assert themselves.Semantic proximity Read ↗

The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.Semantic proximity Read ↗

Ddx1 knockout results in transgenerational wild-type lethality in mice.Semantic proximity Read ↗

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.Semantic proximity Read ↗

ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.Semantic proximity Read ↗

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