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Article

The First Defined Null Allele of the Notch Regulator, a Suppressor of Deltex: Uncovering Its Novel Roles in Drosophila melanogaster Oogenesis.

Biomolecules - 26 Apr 2024

Wilkin Marian B, Whiteford Rory, Akbar Tanveer, Hosseini-Alghaderi Samira, Revici Raluca, Carbery Ann-Marie, Baron Martin

Abstract excerpt

Suppressor of deltex (Su(dx)) is a Drosophila melanogaster member of the NEDD4 family of the HECT domain E3 ubiquitin ligases. Su(dx) acts as a regulator of Notch endocytic trafficking, promoting Notch lysosomal degradation and the down-regulation of both ligand-dependent and ligand-independent signalling, the latter involving trafficking through the endocytic pathway and activation of the endo/lysosomal...

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Source

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Identifiers

PMID: 38785929
DOI: 10.3390/biom14050522
PMCID: PMC11118177

Genes

C2
NEDD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The First Defined Null Allele of the Notch Regulator, a Suppressor of Deltex: Uncovering Its Novel Roles in Drosophila melanogaster Oogenesis.PMID 38785929Read ↗

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