Article

Orb prevents autophagy in the <i>Drosophila</i> germline through translational repression of <i>Atg12</i> mRNA

2014-08-15

Abstract excerpt

Drosophila Orb, the homologue of vertebrate CPEB is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb has also an essential function during early oogenesis which has not been addressed at the molecular level. Here, we show that orb prevents cell death during early stages of oogenesis, thus allowing oogenesis to progress. It does so thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 881048ca-b146-57b5-bae0-28d0312a28d3
DOI: 10.1101/007971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Orb prevents autophagy in the <i>Drosophila</i> germline through translational repression of <i>Atg12</i> mRNADOI 10.1101/007971Read

Translational Control of Autophagy by Orb in the Drosophila Germline.Semantic proximity Read

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late <i>Drosophila melanogaster</i> oogenesisSemantic proximity Read

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesisSemantic proximity Read

Cup blocks the precocious activation of the orb autoregulatory loop.Semantic proximity Read

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.Semantic proximity Read

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.Semantic proximity Read

Autophagy of an Amyloid-like Translational Repressor Regulates Meiotic ExitSemantic proximity Read

Autophagy as a trigger for cell death: Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in DrosophilaSemantic proximity Read

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during <i>Drosophila melanogaster</i> oogenesisSemantic proximity Read

The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.Semantic proximity Read

RNA degradation sculpts the maternal transcriptome during <i>Drosophila</i> oogenesisSemantic proximity Read

Cell death duringDrosophila melanogasterearly oogenesis is mediated through autophagySemantic proximity Read