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Article

Reduction of Cullin-2 in somatic cells disrupts differentiation of germline stem cells in the Drosophila ovary.

Developmental biology - 15 Sept 2015

Ayyub Champakali, Banerjee Kushal Kr, Joti Prakash

Abstract excerpt

Signaling from a niche consisting of somatic cells is essential for maintenance of germline stem cells (GSCs) in the ovary of Drosophila. Decapentaplegic (Dpp), a type of bone morphogenetic protein (BMP) signal, emanating from the niche, is the most important signal for this process. Cullin proteins constitute the core of a multiprotein E3-ligase important for their functions viz. degradation or modification of...

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Source

Identifiers

PMID: 26206612
DOI: 10.1016/j.ydbio.2015.07.019

Genes

GSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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