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Article

No evidence of immunosurveillance in mutation-hotspot driven clonal haematopoiesis

2024-09-30

Abstract excerpt

The theory of immunosurveillance posits that T-cells can selectively eliminate clones harbouring non-self antigens generated by somatic mutations. There is considerable evidence supporting the role of immune surveillance in cancer. Whether immunosurveillance imposes a negative selective pressure on pre-cancerous clones, however, is not well established. Here, we studied the association between MHC-variant binding...

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Literature Corpus work
3b4eede6-41e3-59ba-a3d8-d6290e2b0ba6
DOI
10.1101/2024.09.27.615394
Open publication

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No evidence of immunosurveillance in mutation-hotspot driven clonal haematopoiesisDOI 10.1101/2024.09.27.615394
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