Article

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis

2023-12-14

Abstract excerpt

Clonal hematopoiesis (CH) is a phenomenon of clonal expansion of hematopoietic stem cells driven by somatic mutations affecting certain genes. Recently, CH has been linked to the development of a number of hematologic malignancies, cardiovascular diseases and other conditions. Although the most frequently mutated CH driver genes have been identified, a systematic landscape of the mutations capable of initiating th...

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Literature Corpus work: 9077bb35-0eb3-58eb-a7e0-40f262797066
DOI: 10.1101/2023.12.13.23299893

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