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Article

No evidence of immunosurveillance in mutation-hotspot-driven clonal hematopoiesis.

Nature genetics - 1 Jul 2026

Walkowiak Barbara, MacGregor Hamish A J, Blundell Jamie R

Abstract excerpt

The theory of immunosurveillance posits that T cells eliminate clones harboring nonself-antigens generated by somatic mutations. Although a role of immunosurveillance in cancer is supported by evidence, whether it affects precancerous expansions has not been well established. Here we studied the association between MHC-variant binding and risk of clonal hematopoiesis (CH), a blood precancer state, predicting MHC...

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Identifiers

PMID: 42373856
DOI: 10.1038/s41588-026-02594-y
PMCID: PMC13364711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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